Sodium Bicarbonate → HCID 22283083, compound

HRID 1060299Notes

Reaction equation

HRID 1060299 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13](=[O:15])[OH:14])[S:11][C:7]=2[C:6]([C:16]2[N:17]=[C:18]([NH:21]C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[S:19][CH:20]=2)=[CH:5][CH:4]=1.C([O-])(O)=O.[Na+]>Cl.CO>[NH2:21][C:18]1[S:19][CH:20]=[C:16]([C:6]2[C:7]3[S:11][C:10]([NH:12][C:13](=[O:14])[OH:15])=[N:9][C:8]=3[C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:17]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22283066HCID 22283066, compound

Product 1

HCID 22283083HCID 22283083, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

0.070 g of {4-methoxy-7-[2-(trityl-amino)-thiazol-4-yl]-benzothiazol-2-yl}-carbamic acid methyll ester (0.00012 Mol) were heated to reflux in 2 ml of 2.5 M HCl/MeOH for 4 hrs. After cooling to room temperature the pH was adjusted to 7 upon drop wise addition of sat. NaHCO3. A precipitate formed, which was filtered off, washed with ethyl acetate and dried. The title compound was obtained as a white solid (23%), F.p.: 293-296° C. (dec.).

Workup

  1. customA precipitate formed
  2. filtrationwhich was filtered off
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-be5c9a32596c40e7b2efcc0c32b08985
Source dataset
uspto-grants-2003_02
Patent number
US06521754B2

Reaction notes

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