化工社化工社 化学情報印刷レポート · 研究参考用
2-((4-Chlorophenoxy)methyl)oxirane → N-[2-Hydroxy-3-(4-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-((4-Chlorophenoxy)methyl)oxirane | HCID 91515 | — |
| 反応物 | 2-(4-Methoxyphenyl)-1,1-dimethylethylamine | HCID 91892 | — |
| 生成物 | N-[2-Hydroxy-3-(4-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride | HCID 18459608 | 135.9% |
反応手順
Using the method of Example 6, supra, 4-chlorophenyl glycidyl ether (185 mg, 1 mmol) and 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine (269 mg, 1.5 mmol) were used to prepare 272 mg of the title compound as a white solid: GC/EI-MS, m/z (rel. int.) 348 (M-15, 1), 244 (35), 243 (15), 242 (100), 163 (9), 121 (24), 114 (7), 71 (24), 70 (26), 58 (15), 42 (7).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06521667B1 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-ad0db80498664c0291e43bafc5c176cc |
| 出典メモ | uspto-grants-2003_02 |