Lithium Hydroxide → HCID 54189597, compound

HRID 1060469Notes

Reaction equation

HRID 1060469 reaction equation
C([O:3][C:4](=[O:33])[C@H:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:29]([O:30][CH3:31])=[CH:28][CH:27]=[CH:26][C:25]=2[OH:32])=[CH:20][CH:19]=1)[NH:6][C:7](=[O:16])[C:8]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:15])C.[Li+].[OH-]>>[Cl:14][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:15])[C:8]=1[C:7]([NH:6][C@H:5]([C:4]([OH:33])=[O:3])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:29]([O:30][CH3:31])=[CH:28][CH:27]=[CH:26][C:25]=2[OH:32])=[CH:20][CH:19]=1)=[O:16]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 54105918N-(2,6-dichlorobenzoyl)-4-(6-methoxy-2-hydoxyphenyl)-L-phenylalanine ethyl ester

Product 1

HCID 54189597HCID 54189597, compound

Procedure

N-(2,6-Dichlorobenzoyl)-4-(6-methoxy-2-hydroxyphenyl)-L-phenylalanine ethyl ester was hydrolyzed with LiOH in a similar method as described in Example 1-5) to give the title compound. mp. 224.4° C., ESMS: m/z 460 (MH+), 458 (M−H)−.

Sources & evidence

ORD record
ord-f02439805f0d418fbc7d288b94f53f94
Source dataset
uspto-grants-2003_02
Patent number
US06521666B1

Reaction notes

Loading…