反应详情

To a solution of EtOAc (25 mL) and 5-chloro-4-methoxy-2-nitro-phenylamine (1.6 g, 7.9 mmol) under argon is added 5% Pd/C (0.5 g). The reaction mixture is hydrogenated at 50 psi for 1 hour. The mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc, and the pad is washed with additional EtOAc. The resulting precipitate is filtered off to provide a white solid.

1. filtrationThe mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc
2. washthe pad is washed with additional EtOAc
3. filtrationThe resulting precipitate is filtered off
4. customto provide a white solid