Sodium Hydroxide → Theophylline

HRID 1060519Notes

Reaction equation

HRID 1060519 reaction equation
[OH-:1].[Na+].C1N=C(N)[C:6]2[N:11]=[CH:10][N:9]([C@@H:12]3O[C@H](COP(OP(OC[C@H]4O[C@@H](N5C=C(C(N)=O)CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)[C:7]=2[N:8]=1.[N-]=[N+]=[N-].[Na+].[CH2:51]([NH:55][CH2:56]O)[C:52]([O-])=[O:53].[Na+]>O>[N:11]1([C:52](=[O:53])[C:51]2[NH:55][CH:56]=[N:8][C:7]=2[N:9]([CH3:12])[C:10]1=[O:1])[CH3:6]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 33557Sodium AzideHCID 439153NadhHCID 23664641Sodium N-(hydroxymethyl)glycinate

Product 1

HCID 2153Theophylline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

One liter of a first reagent was prepared as follows. Approximately 800 ml deionized water was dispensed into a container and 6.0 grams of ACES were added and dissolved. The pH was adjusted to 6.0 with 2N NaOH. Then 0.66 grams NAD were added and dissolved completely. Then 0.95 grams sodium azide was added and dissolved, and finally 1.0 gram of SUTTOCIDE A was added and dissolved. The volume was adjusted to one liter with deionized water.

Workup

  1. additionwere added
  2. dissolutiondissolved
  3. dissolutiondissolved completely
  4. dissolutiondissolved
  5. dissolutiondissolved

Sources & evidence

ORD record
ord-b140cd83ce4b4baabf6975a4949a3e5a
Source dataset
uspto-grants-2003_02
Patent number
US06524808B1

Reaction notes

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