Water → 7-Bromo-5-methoxyindoline

HRID 1060626노트

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HRID 1060626 반응식
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:18][CH3:19])=[CH:14][C:15]=2[Br:17])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.CCOCC.O.[OH-].[Na+]>CO.CCOCC>[Br:17][C:15]1[CH:14]=[C:13]([O:18][CH3:19])[CH:12]=[C:11]2[C:16]=1[NH:8][CH2:9][CH2:10]2

참가 물질

7

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 10953452Ether hydrochlorideHCID 186292191h-Indole-1-carboxylic acid,7-bromo-2,3-dihydro-5-methoxy-,1,1-dimethylethyl ester

생성물 1

HCID 184528187-Bromo-5-methoxyindoline수율 85%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

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온도
55 °C

실험 절차

Part D: To 1-(tert-butoxycarbonyl)-7-bromo-5-methoxyindoline (1.16 g) in methanol (28 mL) was added HCl/ether (1.0 M, 14.1 mL, 4 eq.). The reaction was heated at 55° C. for 4 hours and then cooled to room temperature. Water (25 mL) was added and the pH was adjusted to 9 with NaOH (1 N, aq.). The mixture was extrated with ether, which was washed with brine, dried over MgSO4, and concentrated to give 7-bromo-5-methoxyindoline (685 mg).

후처리

  1. temperaturecooled to room temperature
  2. washwas washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b6455703b684674aa8e2c8dcbd56cf6
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525056B2

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