Bromine → Ethyl 2-bromoacetyl-4-methylpentanoate

HRID 1060739Notes

Reaction equation

HRID 1060739 reaction equation
[C:1]([CH:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=[O:3])[CH3:2].[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][CH2:2][C:1]([CH:4]([CH2:10][CH:11]([CH3:12])[CH3:13])[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 538758Pentanoic acid, 2-acetyl-4-methyl-, ethyl ester

Product 1

HCID 86585119Ethyl 2-bromoacetyl-4-methylpentanoate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

A solution comprised of ethyl 2-acetyl-4-methylpentanoate (1.86 gm, 10 mmol) in chloroform (20 mL) was cooled to 0° C. and treated with bromine (0.6 mL, 11.0 mmol in 10 mL chloroform). The mixture was stirred for approximately 12 hours and then concentrated to provide ethyl 2-bromoacetyl-4-methylpentanoate as a crude product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-a3b7e3947a7a4c36b4a2c5c0ff9aa067
Source dataset
uspto-grants-2003_02
Patent number
US06525036B2

Reaction notes

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