Thiobenzamide → Ethyl 4-methyl-2-(2-phenylthiazol-4-yl)pentanoate

Participants

Reaction Steps

A solution comprised of ethyl 2-bromoacetyl-4-methylpentanoate (0.264 gm, 1 mmol) in ethanol (5 mL) was treated with thiobenzamide (0.15 gm, 1.1 mmol). The mixture was heated at refluxed for 1 hour and concentrated to provide ethyl 4-methyl-2-(2-phenylthiazol-4-yl)pentanoate as a crude product.

Provenance & Evidence