Thiobenzamide → Ethyl 4-methyl-2-(2-phenylthiazol-4-yl)pentanoate

HRID 1060740Notes

Reaction equation

HRID 1060740 reaction equation
Br[CH2:2][C:3]([CH:5]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=O.[C:15]([NH2:23])(=[S:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)C>[CH3:13][CH:12]([CH3:14])[CH2:11][CH:5]([C:3]1[N:23]=[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[S:22][CH:2]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 683563ThiobenzamideHCID 86585119Ethyl 2-bromoacetyl-4-methylpentanoate

Product 1

HCID 18628735Ethyl 4-methyl-2-(2-phenylthiazol-4-yl)pentanoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution comprised of ethyl 2-bromoacetyl-4-methylpentanoate (0.264 gm, 1 mmol) in ethanol (5 mL) was treated with thiobenzamide (0.15 gm, 1.1 mmol). The mixture was heated at refluxed for 1 hour and concentrated to provide ethyl 4-methyl-2-(2-phenylthiazol-4-yl)pentanoate as a crude product.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat refluxed for 1 hour
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-314f1efc81fe49c5b04a1a9e51129371
Source dataset
uspto-grants-2003_02
Patent number
US06525036B2

Reaction notes

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