Water → [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester

HRID 106078Notes

Reaction equation

HRID 106078 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][c:5]2[n:6][c:7]([Cl:18])[n:8][c:9]([N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:10]2[s:11]1.[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25]([N:26]([CH:27]1[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1)[CH3:33])=[O:34].[C:35](=[O:36])([O-:37])[O-:38].[Cs+:39].[Cs+:40].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[OH2:19]>>[CH2:2]([c:3]1[cH:4][c:5]2[n:6][c:7]([Cl:18])[n:8][c:9]([N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:10]2[s:11]1)[N:30]1[CH2:29][CH2:28][CH:27]([N:26]([C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:34])[CH3:33])[CH2:32][CH2:31]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27568064-N-Boc-4-N-Methyl-aminopiperidineHCID 461807264-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 59151274[1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-0ca98f5480154ff2ac248b633a977eac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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