Hydrochloric Acid → HCID 22397498, compound

HRID 1060805Notes

Reaction equation

HRID 1060805 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:18][CH2:17][CH:16]([O:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([F:27])[CH:21]=3)[CH2:15][CH2:14]2)[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:8]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:14][CH2:15][CH:16]([O:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([F:27])[CH:21]=3)[CH2:17][CH2:18]2)[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69429651HCID 69429651, compound

Product 1

HCID 22397498HCID 22397498, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of Step c was dissolved in dioxane (10 ml) and HCl (6N) (10 ml) was added and the reaction stirred for 3 hrs. Organic solvent was evaporated and aqueous NaOH (2M) added. The product was extracted with ethyl acetate, the combined organic extracts dried with Na2SO4 and concentrated to give the sub-title product as an oil (0.54 g).

Workup

  1. customOrganic solvent was evaporated
  2. additionaqueous NaOH (2M) added
  3. extractionThe product was extracted with ethyl acetate
  4. dry with materialthe combined organic extracts dried with Na2SO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-b64c8bec90fe406099b220ab82de58be
Source dataset
uspto-grants-2003_02
Patent number
US06525070B2

Reaction notes

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