反应详情

4-Methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (11.18 g) and 3,4-dichlorothiophenol (6.15 ml) were stirred together in acetonitrile (200 ml) and potassium carbonate (8.86 g) was added. The mixture was heated at reflux for 18 hours after which water was added and the resulting mixture extracted with dichloromethane. The organic extracts were combined, washed with water, dried (MgSO4) and evaporated to give the sub-title compound (14.58 g).

1. temperatureThe mixture was heated
2. additionwas added
3. extractionthe resulting mixture extracted with dichloromethane
4. washwashed with water
5. dry with materialdried (MgSO4)
6. customevaporated