反应详情

To a solution of 3-methoxybenzenesulfonyl chloride (3.53 g, 12.1 mmol) and triethylamine (3.45 g, 17.1 mmol) in acetone at 0° C. was added 3-amino propionic acid ethyl ester hydrochloride (2.00 g, 17.1 mmol) under a nitrogen atmosphere. After 4 days, the reaction was concentrated in vacuo. The residue was partitioned between 0.1 N HCl solution and EtOAc, the organic layer separated, washed with brine, dried (Na2SO4), and concentrated in vacuo to provide the crude product which was used without further purification.

1. concentrationthe reaction was concentrated in vacuo
2. customThe residue was partitioned between 0.1 N HCl solution and EtOAc
3. customthe organic layer separated
4. washwashed with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo