反应详情

m-Methoxybenzenesulfonyl chloride (3.53 g, 0.017 mol) and Et3N (4.76 mL, 0.034 mol) were dissolved in acetone (35 mL) at 0° C. β-Alanine ethyl ester hydrochloride (2.0 g, 0.017 mol) was added and stirring was continued at room temperature under N2 for 0.5 h. The reaction mixture was concentrated, partitioned between 0.1N HCl solution and EtOAc. The aqueous layer was washed with EtOAc, the organics combined, washed with H2O, brine, and dried (Na2SO4). Filtration and concentration to dryness gave the title compound which was used without further purification.

1. additionwas added
2. concentrationThe reaction mixture was concentrated
3. custompartitioned between 0.1N HCl solution and EtOAc
4. washThe aqueous layer was washed with EtOAc
5. washwashed with H2O, brine
6. dry with materialdried (Na2SO4)
7. filtrationFiltration and concentration to dryness