1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride → 1-[[(6RS)-6-(N-tert-Butoxycarbonylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride	HCID 22709766	—
Reactant	Methyl 6-(((tert-butoxycarbonyl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylate	HCID 22709912	—
Product	1-[[(6RS)-6-(N-tert-Butoxycarbonylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine	HCID 22710919	—

Reaction Steps

In a similar manner to Referential Example 48 except for the use of (2RS)-2-(N-tert-butoxycarbonylaminomethyl)-6-methoxycarbonyl-1,2,3,4-tetrahydronaphthalene and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride, the reaction was conducted, whereby the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06525042B1
Source dataset	uspto-grants-2003_02
ORD ID	ord-9bca2da8c2604eaeb0251227188d610a
Source note	uspto-grants-2003_02