4-(2-Amino-1,3-thiazol-4-yl)benzoic acid → 1-[4-(2-Aminothiazol-4-yl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride

HRID 1061060Notes

Reaction equation

HRID 1061060 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=2)[N:6]=1.Cl.[Cl:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[CH:24]=[C:23]([S:28]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)(=[O:30])=[O:29])[CH:22]=[CH:21]2>>[ClH:17].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([C:11]([N:34]3[CH2:33][CH2:32][N:31]([S:28]([C:23]4[CH:22]=[CH:21][C:20]5[C:25](=[CH:26][CH:27]=[C:18]([Cl:17])[CH:19]=5)[CH:24]=4)(=[O:30])=[O:29])[CH2:36][CH2:35]3)=[O:13])=[CH:14][CH:15]=2)[N:6]=1

Participants

3

Reactant 2

HCID 6131794-(2-Amino-1,3-thiazol-4-yl)benzoic acidHCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

Product 1

HCID 227101101-[4-(2-Aminothiazol-4-yl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride

Procedure

In a similar manner to Example 4 except for the use of 4-(2-aminothiazol-4-yl)benzoic acid and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride as the raw materials, the reaction was conducted, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-7dd208d474764bc08be8ff66d672a29a
Source dataset
uspto-grants-2003_02
Patent number
US06525042B1

Reaction notes

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