Trifluoroacetic acid → HCID 11377163, compound

HRID 1061076Notes

Reaction equation

HRID 1061076 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([CH:15]1[NH:20][CH2:19][C:18]2[S:21][C:22]([C:24]([N:26]3[CH2:31][CH2:30][N:29]([S:32]([C:35]4[CH:44]=[CH:43][C:42]5[C:37](=[CH:38][CH:39]=[C:40]([Cl:45])[CH:41]=5)[CH:36]=4)(=[O:34])=[O:33])[CH2:28][CH:27]3[C:46](=[O:48])[NH2:47])=[O:25])=[N:23][C:17]=2[CH2:16]1)=O)(C)(C)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:46]([CH:27]1[CH2:28][N:29]([S:32]([C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([Cl:45])[CH:41]=3)[CH:36]=2)(=[O:34])=[O:33])[CH2:30][CH2:31][N:26]1[C:24]([C:22]1[S:21][C:18]2[CH2:19][NH:20][CH2:15][CH2:16][C:17]=2[N:23]=1)=[O:25])(=[O:48])[NH2:47]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22710649HCID 22710649, compound

Product 1

HCID 11377163HCID 11377163, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To trifluoroacetic acid (1 ml), a solution of 1-[(6-tert-butoxycarbonyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-2-carbamoyl-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine (303 mg) dissolved in dichloromethane (1 ml) was added, followed by concentration under reduced pressure. The resulting precipitate was collected by filtration and washed with diethyl ether, whereby the title compound (263 mg, 83%) was obtained.

Workup

  1. additionwas added
  2. concentrationfollowed by concentration under reduced pressure
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with diethyl ether, whereby the title compound (263 mg, 83%)
  5. customwas obtained

Sources & evidence

ORD record
ord-0f5374da0df14489bb0ce4e7ffeff857
Source dataset
uspto-grants-2003_02
Patent number
US06525042B1

Reaction notes

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