Norfenefrine → HCID 22220486, compound

HRID 1061409Notes

Reaction equation

HRID 1061409 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[Cl:16][C:17]1[C:18]([O:27][C:28]2[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=2)=[N:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1.[CH:38]1[CH:43]=[C:42]([OH:44])[CH:41]=[C:40]([CH:45]([OH:48])[CH2:46][NH2:47])[CH:39]=1>>[Cl:16][C:17]1[C:18]([O:27][C:28]2[CH:33]=[CH:32][C:31]([S:34]([NH:2][C:3]3[CH:8]=[CH:7][C:6]([N:9]4[CH2:14][CH2:13][CH:12]([NH:47][CH2:46][CH:45]([OH:48])[C:40]5[CH:39]=[CH:38][CH:43]=[C:42]([OH:44])[CH:41]=5)[CH2:11][CH2:10]4)=[CH:5][CH:4]=3)(=[O:36])=[O:35])=[CH:30][CH:29]=2)=[N:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1

Participants

4

Reactant 3

HCID 4538NorfenefrineHCID 27830394-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}benzene-1-sulfonyl chlorideHCID 222202401-(4-Amino-phenyl)-piperidin-4-one hydrochloride

Product 1

HCID 22220486HCID 22220486, compound

Procedure

The title compound was prepared from 1-(4-aminophenyl)-4-piperidone hydrochloride (which was obtained in Example 224), 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)benzenesulfonyl chloride, and DL-norphenylephrine according to the procedure of Example 346; MS (ES) m/z: 663.2 (MH+).

Sources & evidence

ORD record
ord-d1c66cfe334d4363b9ef08d04997fc2a
Source dataset
uspto-grants-2003_02
Patent number
US06525202B2

Reaction notes

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