Nitric Acid → HCID 86586471, compound

HRID 1061464Notes

Reaction equation

HRID 1061464 reaction equation
[F:1][CH:2]([F:11])[C:3]1[C:4]([CH3:10])=[N+:5]([O-:9])[CH:6]=[CH:7][CH:8]=1.O.[N+:13]([O-])([OH:15])=[O:14]>S(=O)(=O)(O)O>[F:11][CH:2]([F:1])[C:3]1[C:4]([CH3:10])=[N+:5]([O-:9])[CH:6]=[CH:7][C:8]=1[N+:13]([O-:15])=[O:14]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 67356126HCID 67356126, compound

Product 1

HCID 86586471HCID 86586471, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Conditions

Temperature
95 °C

Procedure

31.38 g of 3-difluoromethyl-2-methylpyridine N-oxide (XVII) was dissolved in 64 ml of concentrated sulfuric acid, to which a mixed solution of 93 ml of concentrated sulfuric acid and 107 ml of 65% nitric acid were added, and the resulting mixture was heated at 95° C. for 20 hours. The reaction solution was poured into iced water and the precipitated crystal was separated by filtering to obtain 17.79 g of 3-difluoromethyl-2-methyl-4-nitropyridine N-oxide (XVIII).

Workup

  1. additionwere added
  2. customthe precipitated crystal was separated
  3. filtrationby filtering

Sources & evidence

ORD record
ord-b75d9113f8a3471d9ac10ff2ca321c2a
Source dataset
uspto-grants-2003_02
Patent number
US06525066B2

Reaction notes

Loading…