Nitric Acid → HCID 86586471, compound

Participants

Reaction Conditions

Reaction Steps

31.38 g of 3-difluoromethyl-2-methylpyridine N-oxide (XVII) was dissolved in 64 ml of concentrated sulfuric acid, to which a mixed solution of 93 ml of concentrated sulfuric acid and 107 ml of 65% nitric acid were added, and the resulting mixture was heated at 95° C. for 20 hours. The reaction solution was poured into iced water and the precipitated crystal was separated by filtering to obtain 17.79 g of 3-difluoromethyl-2-methyl-4-nitropyridine N-oxide (XVIII).

Provenance & Evidence