3,5-Dichloro-2,4,6-trifluoropyridine → 4-Pyridinamine, 3,5-dichloro-2,6-difluoro-

HRID 1061497Notes

Reaction equation

HRID 1061497 reaction equation
[Cl:1][C:2]1[C:3]([F:11])=[N:4][C:5]([F:10])=[C:6]([Cl:9])[C:7]=1F.[NH2:12]C1C(F)=C(F)N=C(F)C=1Cl>>[NH2:12][C:7]1[C:2]([Cl:1])=[C:3]([F:11])[N:4]=[C:5]([F:10])[C:6]=1[Cl:9]

Participants

3

Reactant 2

HCID 612733,5-Dichloro-2,4,6-trifluoropyridineHCID 34881444-Amino-3-chloro-2,5,6-trifluoro-pyridine

Product 1

HCID 760894-Pyridinamine, 3,5-dichloro-2,6-difluoro-

Procedure

This compound was prepared from 3,5-dichloro-2,4,6-trifluoropyridine (24.5 g) by a procedure similar to that described for compound 2: yield, 23.7 g (98%); mp 110° C. (Lit., Chambers et al., J. Chem. Soc. 1964, 5634-5640 mp 112-113° C.).

Workup

  1. customyield

Sources & evidence

ORD record
ord-3c492f8194474dd3a0abf35b748976b2
Source dataset
uspto-grants-2005_11
Patent number
US06960568B2

Reaction notes

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