反应详情

4-chloro-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-3-ylamine (0.300 g) was dissolved in THF (5 ml) with stirring and then cooled in ice-water bath to below 0° C., to this added 48% aqueous fluoboric acid (0.7 ml) and mixture stirred for 10 mins. A solution of sodium nitrite (0.10 sg) in water (1 ml) was added keeping the temperature below 10° C. The reaction mixture was the stirred for 1 hr, during that time yellow solid precipitated. This solid was filtered, dried to give 4-chloro-6-methoxy-7-(3-piperidin-1-yl-propoxy)-quinolin-3-diazonium tetrafluoroborate (0.250 g, 80%)

1. customthe temperature below 10° C
2. stirringstirred for 1 hr, during that time yellow solid
3. customprecipitated
4. filtrationThis solid was filtered
5. customdried