2-Bromopyridine → (3S)-3-methyl-1-pyridin-2-ylpiperazine

HRID 1061571Notes

Reaction equation

HRID 1061571 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Br[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>>[CH3:1][C@@H:2]1[NH:3][CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:7]1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 27342192-Methylpiperazine, (S)-

Product 1

HCID 1519492(3S)-3-methyl-1-pyridin-2-ylpiperazineYield 67.7%

Conditions

Temperature
120 °C

Procedure

(S)-(+)-2-Methylpiperazine (0.50 g, 0.005 mol, Aldrich) and 2-bromopyridine (5 mL, 0.05 mol) were combined and heated at 120° C. for 14 hours. The reaction mixture was allowed to cool to 23° C. and partitioned between ethyl acetate and water. The layers were separated, and the water layer extracted twice with ethyl acetate. The aqueous phase was brought to pH ˜11 with a solution of saturated sodium bicarbonate and solid sodium carbonate. Sodium chloride was added, and the saturated aqueous solution was extracted with ethyl acetate (2×) and dichloromethane (2×). The combined organic extracts were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure to afford 0.6 g (67% yield) of the title compound. 1H NMR (400 MHz, DMSO-d6) δ 1.02 (d, J=6.0 Hz, 3H), 2.27 (dd, J=10, 12 Hz, 1), 2.67 (m, 3H), 2.92 (m, 1H), 4.07 (m, 2H), 6.58 (dd, J=6, 8 Hz, 1H), 6.77 (d, J=8 Hz, 1H), 7.49 (m, 1H), 8.08 (m, 1H); MS (ESI) m/e 178 (M+H)+.

Workup

  1. temperatureto cool to 23° C.
  2. custompartitioned between ethyl acetate and water
  3. customThe layers were separated
  4. extractionthe water layer extracted twice with ethyl acetate
  5. additionSodium chloride was added
  6. extractionthe saturated aqueous solution was extracted with ethyl acetate (2×) and dichloromethane (2×)
  7. dry with materialThe combined organic extracts were dried over Na2SO4
  8. filtrationfiltered
  9. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-d7ec336bf10644b48fa6f723da0b9613
Source dataset
uspto-grants-2005_11
Patent number
US06960589B2

Reaction notes

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