HCID 22229205, compound → HCID 22285081, compound

HRID 1061589Notes

Reaction equation

HRID 1061589 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:35]=[CH:34][C:13]([CH2:14][NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21](C(OCC3C=CC=CC=3)=O)[CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:35]=[CH:34][C:13]([CH2:14][NH:15][C:16]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)=[O:17])=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 22229205HCID 22229205, compound

Product 1

HCID 22285081HCID 22285081, compoundYield 100.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

41.7 g (86.4 mmol) of benzyl 4-[4-(tert-butyloxycarbonylaminomethyl)benzylaminocarbonyl]piperazine-1-carboxylate (starting material A11 ) in 1.0 l of methanol are hydrogenated over palladium/carbon (5%) for 4 h. The catalyst is filtered off and the solvent is removed, giving 30.3 g of the title compound as a colorless oil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed

Sources & evidence

ORD record
ord-6127ea637c3046768bd0af53d479d8be
Source dataset
uspto-grants-2005_11
Patent number
US06960588B1

Reaction notes

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