Ammonia → (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

HRID 1061655Notes

Reaction equation

HRID 1061655 reaction equation
[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4](OC(C)C)=[O:5].[NH3:18]>CO>[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4]([NH2:18])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11736536isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate

Product 1

HCID 57310726(2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate (200 mg, Reference compound No. 4-1) in methanol (3 ml) is saturated with an ammonia gas, and the solution is sealed and stirred overnight. The reaction solution is concentrated under reduced pressure to give the titled reference compound (162 mg).

Workup

  1. customthe solution is sealed
  2. concentrationThe reaction solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-8aa7d5ce399044a19095ca39e8c1e607
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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