HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate | HCID 11736536 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide | HCID 57310726 | — |
Reaction Steps
A solution of isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate (200 mg, Reference compound No. 4-1) in methanol (3 ml) is saturated with an ammonia gas, and the solution is sealed and stirred overnight. The reaction solution is concentrated under reduced pressure to give the titled reference compound (162 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960575B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-8aa7d5ce399044a19095ca39e8c1e607 |
| Source note | uspto-grants-2005_11 |