Hydrochloric Acid → HCID 14503250, compound

HRID 1061661Notes

Reaction equation

HRID 1061661 reaction equation
[ClH:1].C([NH:10][CH:11]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:12]([OH:17])[C:13]([F:16])([F:15])[F:14])(=O)C1C=CC=CC=1.C(O)C>O>[ClH:1].[NH2:10][CH:11]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:12]([OH:17])[C:13]([F:14])([F:15])[F:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14503244HCID 14503244, compound

Product 1

HCID 14503250HCID 14503250, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12 N Hydrochloric acid is added to a suspension of (2RS, 3RS)-3-benzoylamino-2-hydroxy-4-phenyl-1,1,1-trifluorobutane (3.00 g, Reference compound No. 31-1), ethanol (60 ml) and water (60 ml), and the mixture is refluxed for one day. After standing, the reaction mixture is concentrated under reduced pressure, diethyl ether is added to the resulting residue, and the whole is extracted with water. The extract is concentrated under reduced pressure to give the titled reference compound (1.58 g).

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure, diethyl ether
  2. additionis added to the resulting residue
  3. extractionthe whole is extracted with water
  4. concentrationThe extract is concentrated under reduced pressure

Sources & evidence

ORD record
ord-38d4779711934e15b305dd15cefeae5f
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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