Hydrogen chloride-ethyl acetate → HCID 69749936, compound

HRID 1061697Notes

Reaction equation

HRID 1061697 reaction equation
[ClH:1].C(OCC)(=O)C.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21](=[O:55])[C@@H:22]([NH:30][C:31]([CH2:33][N:34]2[C:39]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)=[CH:38][N:37]([C:46](=[O:50])[CH2:47][O:48][CH3:49])[CH:36]([CH:51]([CH3:53])[CH3:52])[C:35]2=[O:54])=[O:32])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>C(OCC)(=O)C>[ClH:1].[CH:51]([CH:36]1[N:37]([C:46](=[O:50])[CH2:47][O:48][CH3:49])[CH:38]=[C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[N:34]([CH2:33][C:31]([NH:30][C@@H:22]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21](=[O:55])[N:18]2[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]2)=[O:32])[C:35]1=[O:54])([CH3:53])[CH3:52]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69749438HCID 69749438, compound

Product 1

HCID 69749936HCID 69749936, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 4 N hydrogen chloride/ethyl acetate solution (0.24 ml) is added to a solution of (2S)-1-(4-tert-butoxycarbonylpiperazin-1-yl)-2-{(3RS)-3-isopropyl-4-methoxyacetyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrazin-1-yl}methylcarbonylamino-1-oxo-3-phenylpropane (190 mg, Compound No. 1-55) in ethyl acetate (3 ml), and the mixture is stirred for one hour. The reaction mixture is concentrated under reduced pressure to give the titled compound (146 mg).

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure

Sources & evidence

ORD record
ord-d506b005055b42b8b82ce696237d278b
Source dataset
uspto-grants-2005_11
Patent number
US06960575B2

Reaction notes

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