HCID 22285712, compound → HCID 22285726, compound

HRID 1061732Notes

Reaction equation

HRID 1061732 reaction equation
[OH:1][CH:2]([CH3:17])[CH2:3][N:4]1[C:12]2=[C:13]([OH:16])[CH:14]=[CH:15][C:10]3=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9]3)=[N:5]1>C(O)C>[CH2:15]([O:16][C:13]1[C:12]2[N:4]([CH2:3][CH:2]([OH:1])[CH3:17])[N:5]=[C:6]3[CH2:7][CH2:8][CH2:9][C:10]([C:11]=23)=[CH:15][CH:14]=1)[C:10]1[CH:11]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 22285712HCID 22285712, compound

Product 1

HCID 22285726HCID 22285726, compoundYield 109.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of the product from Step D (0.59 g, 2.6 mmol) in ethanol (20 mL) was treated as described in Step F of Example 1 to provide a solid (0.46 g, 54%): m.p 95-97° C.; MS (ES) m/z 323 (M+); 1H NMR (CDCl3) δ 7.34 (5H, m), 7.14 (1H, s), 5.08 (2H, s), 4.31 (2H, m), 4.13 (2H, m), 3.02 (5H, m), 2.19 (3H, m), 1.27(3H, t, J=6.0 Hz).

Sources & evidence

ORD record
ord-e42ec2069796404bb53584142fe90db2
Source dataset
uspto-grants-2005_11
Patent number
US06960608B2

Reaction notes

Loading…