HRID1061762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID118939

2-Bromo-4-fluorobenzonitrile

C7H3BrFN

反应SMILES：CC1(C)OB(c2cc([N+](=O)[O-])ccc2F)OC1(C)C

HCID3833297

2-(2-Fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

C12H15BFNO4

PRODUCTS

产物

反应SMILES：N#Cc1ccc(F)cc1-c1cc([N+](=O)[O-])ccc1F

HCID22285285

2′,5-Difluoro-5′-nitro[1,1′-biphenyl]-2-carbonitrile

C13H6F2N2O2

PROCEDURE

实验过程

2-Bromo-4-fluorobenzonitrile was coupled to 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane as described in Example 7 part c) to give 5,2′-difluoro-5′-nitrobiphenyl-2-carbonitrile as a black solid: δH (360 MHz, CDCl3) 7.25-7.33 (2H, m), 7.40-7.44 (1H, m), 7.86 (1H, dd, J 9 and 6), 8.35-8.42 (2H, m).