反应详情

A solution of 2-chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine (800 mg, 3.2 mmol) in ethanol (300 mL) was reduced under 40 p.s.i. hydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered to give a solution of 3-(2-chloro-pyrimidin-4-yl)-4-fluorophenylamine: m/z (ES+) 224 (M++H).

1. filtrationhydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered