HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-fluorophenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine | HCID 22285326 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Chloropyrimidin-4-yl)-4-fluorophenylamine | HCID 22285292 | — |
Reaction Steps
A solution of 2-chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine (800 mg, 3.2 mmol) in ethanol (300 mL) was reduced under 40 p.s.i. hydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered to give a solution of 3-(2-chloro-pyrimidin-4-yl)-4-fluorophenylamine: m/z (ES+) 224 (M++H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960598B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-3fec487d64514a7bbd2d1701dfe3d3c0 |
| Source note | uspto-grants-2005_11 |