反应详情

To the solution of 3-(2-chloro-pyrimidin-4-yl)-4-fluorophenylamine from above was added triethylamine (0.48 mL, 3.15 mmol) and palladium on active carbon (100 mg, 10% palladium) and the mixture was reduced under 40 p.s.i. hydrogen for 30 minutes. The mixture was filtered and the solvent removed to give 4-fluoro-3-pyrimidin-4-yl-phenylamine as a yellow solid: m/z (ES+) 190 (M++H).

1. filtrationThe mixture was filtered
2. customthe solvent removed