HRID1061877

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1ccc2cc(C(=O)c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)ccc2c1CBr

HCID22285043

未命名化合物

HCID57454252

未命名化合物

PRODUCTS

生成物

结构：CN1Cc2c(ccc3cc(C(=O)c4cn(C(c5ccccc5)(c5ccccc5)c5ccccc5)cn4)ccc23)C1=O

HCID22285042

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Methyl 1-bromomethyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthoate (14.0 g) was dissolved in THF (120 mL), and 40% methylamine methanol solution (60 mL) was added. The reaction mixture was stirred at room temperature for 20 hrs. and the solvent was evaporated. The residue was purified by column chromatography (carrier: silica gel, developing solvent: dichloromethane-methanol=40:1) and crystallized from ethyl acetate-diethyl ether to give the title compound (5.5 g) as colorless crystals.

WORKUP

后处理

customand the solvent was evaporated
customThe residue was purified by column chromatography (carrier: silica gel, developing solvent: dichloromethane-methanol=40:1)
customcrystallized from ethyl acetate-diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-48e32a1271b2403b9252250ad8ea8853
来源数据集: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06960586B2
来源说明: uspto-grants-2005_11

反应 SMILES

Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([C:15]3[N:16]=[CH:17][N:18]([C:20](C4C=CC=CC=4)([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH:19]=3)=[O:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:39]([O:41]C)=O.CO.[CH3:45][NH2:46]>C1COCC1>[CH3:45][N:46]1[CH2:2][C:3]2[C:12]3[CH:11]=[CH:10][C:9]([C:13]([C:15]4[N:16]=[CH:17][N:18]([C:20]([C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)([C:21]5[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=5)[C:3]5[CH:12]=[CH:7][CH:6]=[CH:5][CH:4]=5)[CH:19]=4)=[O:14])=[CH:8][C:7]=3[CH:6]=[CH:5][C:4]=2[C:39]1=[O:41]