Cyclopropylamine → HCID 178450029, compound

HRID 1061887Notes

Reaction equation

HRID 1061887 reaction equation
Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:41])([C:17]3[N:18]=[CH:19][N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:21]=3)[CH:14]([CH3:16])[CH3:15])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:42](OC)=[O:43].[CH:46]1([NH2:49])[CH2:48][CH2:47]1>>[CH:46]1([N:49]2[CH2:2][C:3]3[C:12]4[CH:11]=[CH:10][C:9]([C:13]([OH:41])([C:17]5[N:18]=[CH:19][NH:20][CH:21]=5)[CH:14]([CH3:16])[CH3:15])=[CH:8][C:7]=4[CH:6]=[CH:5][C:4]=3[C:42]2=[O:43])[CH2:48][CH2:47]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 22285061Methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

Product 1

HCID 178450029HCID 178450029, compound

Procedure

By a ring closure reaction, a detritylation reaction and purification in the same manner as in Example 1 using methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate (1.32 g) and cyclopropylamine (3.0 ml), the title compound (0.58 g) was obtained as a colorless amorphous solid.

Workup

  1. customBy a ring closure reaction

Sources & evidence

ORD record
ord-257444ca33ea41e8ae9a54413453c9cb
Source dataset
uspto-grants-2005_11
Patent number
US06960586B2

Reaction notes

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