Ethanamine, 2,2,2-trifluoro- → HCID 178450031, 화합물

HRID 1061888노트

반응식

HRID 1061888 반응식
Br[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:41])([C:17]3[N:18]=[CH:19][N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:21]=3)[CH:14]([CH3:16])[CH3:15])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:42](OC)=[O:43].[F:46][C:47]([F:51])([F:50])[CH2:48][NH2:49]>>[OH:41][C:13]([C:9]1[CH:10]=[CH:11][C:12]2[C:3]3[CH2:2][N:49]([CH2:48][C:47]([F:51])([F:50])[F:46])[C:42](=[O:43])[C:4]=3[CH:5]=[CH:6][C:7]=2[CH:8]=1)([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)[CH:14]([CH3:16])[CH3:15]

참가 물질

3

반응물 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 22285061Methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate

생성물 1

HCID 178450031HCID 178450031, 화합물

실험 절차

By a ring closure reaction, a detritylation reaction and purification in the same manner as in Example 1 using methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate (0.66 g) and 2,2,2-trifluoroethylamine (2.0 ml), the title compound (0.34 g) was obtained as a colorless amorphous solid.

후처리

  1. customBy a ring closure reaction

출처 및 근거

ORD 기록
ord-120db2486d1d428fa368800fbfacb67c
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960586B2

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