反应详情

温度

60 °C

7-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one (100 mg) was dissolved in 90% formic acid (1 mL) and THF (1 mL) and the mixture was stirred with heating at 60° C. for 30 min. The reaction mixture was concentrated, and saturated aqueous sodium hydrogen carbonate was added to the residue. The mixture was extracted with a mixed solution of ethyl acetate-THF (1:1), dried and concentrated, and the residue was purified by silica gel chromatography to give the title compound (48 mg) as a colorless powder.

1. concentrationThe reaction mixture was concentrated
2. additionsaturated aqueous sodium hydrogen carbonate was added to the residue
3. extractionThe mixture was extracted with a mixed solution of ethyl acetate-THF (1:1)
4. customdried
5. concentrationconcentrated
6. customthe residue was purified by silica gel chromatography