(2'-Chloro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester → Carbamic acid,(3-amino-2'-chloro[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester

HRID 1061970Notes

Reaction equation

HRID 1061970 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592813(2'-Chloro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Product 1

HCID 69592803Carbamic acid,(3-amino-2'-chloro[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (2′-chloro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example C8) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a white solid (180 mg).

Sources & evidence

ORD record
ord-f17211e8b781412385ba9f42ac019227
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

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