Methyl 3-(1H-1,2,4-triazol-1-YL)benzoate → 3-Oxo-3-(3-[1,2,4]triazol-1-yl-phenyl)-propionic acid tert-butyl ester

HRID 1062001Notes

Reaction equation

HRID 1062001 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([CH:13]=[CH:14][CH:15]=2)[C:9]([O:11]C)=O)[CH:5]=[N:4][CH:3]=[N:2]1.[C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[CH3:17].[Li]>>[C:20]([O:19][C:16](=[O:18])[CH2:17][C:9](=[O:11])[C:8]1[CH:13]=[CH:14][CH:15]=[C:6]([N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)[CH:7]=1)([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 22224836Methyl 3-(1H-1,2,4-triazol-1-YL)benzoateHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 695928073-Oxo-3-(3-[1,2,4]triazol-1-yl-phenyl)-propionic acid tert-butyl ester

Procedure

Prepared from methyl 3-[1,2,4]triazol-1-yl-benzoate [CAS-No. 167626-27-9] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange liquid (2.41 g).

Sources & evidence

ORD record
ord-d27e807de93d43e0a371ce8c8c22b9f5
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

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