6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one → {2-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-4-pyridin-2-yl-phenyl}-carbamic acid tert.-butyl ester

HRID 1062044Notes

Reaction equation

HRID 1062044 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:3])[CH3:2].[Cl:22][C:23]1[CH:27]=[CH:26][S:25][C:24]=1[C:28]1[O:33]C(C)(C)[O:31][C:30](=O)[CH:29]=1>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][C:9]=1[NH:20][C:30](=[O:31])[CH2:29][C:28]([C:24]1[S:25][CH:26]=[CH:27][C:23]=1[Cl:22])=[O:33])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222247756-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 59737408(2-Amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 86588001{2-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-4-pyridin-2-yl-phenyl}-carbamic acid tert.-butyl ester

Procedure

Prepared from (2-amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester (Example G17) and 6-(3-chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J2) according to the general procedure K. Obtained as an amorphous brown solid (145 mg).

Sources & evidence

ORD record
ord-57880d1fc9f94136bc7e347c46d3137f
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

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