HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one → {2-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-4-pyridin-2-yl-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one | HCID 22224775 | — |
| Reactant | (2-Amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester | HCID 59737408 | — |
| Product | {2-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-4-pyridin-2-yl-phenyl}-carbamic acid tert.-butyl ester | HCID 86588001 | — |
Reaction Steps
Prepared from (2-amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester (Example G17) and 6-(3-chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J2) according to the general procedure K. Obtained as an amorphous brown solid (145 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-57880d1fc9f94136bc7e347c46d3137f |
| Source note | uspto-grants-2005_11 |