HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-[7-(2,4-Difluoro-phenyl)-4-oxo-4,5-dihydro-3h-benzo [b][1,4]diazepin-2-yl]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-2',4'-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588070 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[7-(2,4-Difluoro-phenyl)-4-oxo-4,5-dihydro-3h-benzo [b][1,4]diazepin-2-yl]-benzonitrile | HCID 22224655 | — |
Reaction Steps
Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-2′,4′-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K85) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (37 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-a0cc95f1d8684a45a1447d2a01488d2d |
| Source note | uspto-grants-2005_11 |