Trifluoroacetic acid → 3-[7-(2,4-Difluoro-phenyl)-4-oxo-4,5-dihydro-3h-benzo [b][1,4]diazepin-2-yl]-benzonitrile

HRID 1062225Notes

Reaction equation

HRID 1062225 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2C=C[C:17]([F:20])=[CH:16][C:15]=2F)=[CH:10][C:9]=1[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=O)(C)(C)C.[C:37](O)([C:39]([F:42])(F)F)=O>C(Cl)Cl>[F:42][C:39]1[CH:37]=[C:17]([F:20])[CH:16]=[CH:15][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:25]([C:27]3[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=3)[C:33]#[N:34])[CH2:24][C:23](=[O:35])[NH:22][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588070{3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-2',4'-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Product 1

HCID 222246553-[7-(2,4-Difluoro-phenyl)-4-oxo-4,5-dihydro-3h-benzo [b][1,4]diazepin-2-yl]-benzonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-2′,4′-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K85) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (37 mg).

Sources & evidence

ORD record
ord-a0cc95f1d8684a45a1447d2a01488d2d
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

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