1,4-Dioxane-2,6-dione → HCID 22286965, compound

HRID 1062313Notes

Reaction equation

HRID 1062313 reaction equation
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][O:3][CH2:2]1.[CH3:9][N:10]1[C:14]([C:15]([NH2:17])=[O:16])=[C:13]([NH2:18])[C:12]([CH2:19][CH2:20][CH3:21])=[N:11]1>ClCCl>[NH2:17][C:15]([C:14]1[N:10]([CH3:9])[N:11]=[C:12]([CH2:19][CH2:20][CH3:21])[C:13]=1[NH:18][C:5]([CH2:4][O:3][CH2:2][C:1]([OH:7])=[O:8])=[O:6])=[O:16]

Participants

4

Reactant 2

HCID 782321,4-Dioxane-2,6-dioneHCID 33380444-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Product 1

HCID 22286965HCID 22286965, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.1 13.5 g of diglycolic anhydride are added at 15° to a solution of 20.5 g of 1-methyl-3-propyl4-amino-5-aminocarbonyl-1H-pyrazole (“Z6”) in 400 ml of dichloromethane, and the mixture is stirred for a further 1 hour. The mixture is subjected to conventional work-up, giving 32.5 g of [(5-aminocarbonyl-1-methyl-3-propyl-1H-pyrazol4-ylcarbamoyl)methoxy]-acetic acid (“Z7”).

Sources & evidence

ORD record
ord-f06a7813e4d24c469ce98386330f78a3
Source dataset
uspto-grants-2005_11
Patent number
US06960661B2

Reaction notes

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