Sodium Hydroxide → HCID 69730921, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of [3-(3-phenyl-acryloylamino)-phenoxy]-acetic acid methyl ester (8) (0.345 g, 1.1 mmol) in tetrahydrofuran (6 ml) a solution of NaOH (0.130 g, 3.3 mmol) in water (6 ml) was added and the resulting mixture was stirred for 3 hours at 35° C. Tetrahydrofuran was evaporated and the remaining water mixture was acidified with 2N HCl to pH 3. The precipitate was filtered off and dried to give 0.300 g (92%) of the title product 9, which was used in the next step without an additional purification.

Provenance & Evidence