Sodium Hydroxide → HCID 69730921, compound

HRID 1062361Notes

Reaction equation

HRID 1062361 reaction equation
C[O:2][C:3](=[O:23])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13](=[O:22])[CH:14]=[CH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:7]=1.[OH-].[Na+]>O1CCCC1.O>[C:16]1([CH:15]=[CH:14][C:13]([NH:12][C:8]2[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=2)[O:5][CH2:4][C:3]([OH:23])=[O:2])=[O:22])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 69729781HCID 69729781, compound

Product 1

HCID 69730921HCID 69730921, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
35 °C

Procedure

To a suspension of [3-(3-phenyl-acryloylamino)-phenoxy]-acetic acid methyl ester (8) (0.345 g, 1.1 mmol) in tetrahydrofuran (6 ml) a solution of NaOH (0.130 g, 3.3 mmol) in water (6 ml) was added and the resulting mixture was stirred for 3 hours at 35° C. Tetrahydrofuran was evaporated and the remaining water mixture was acidified with 2N HCl to pH 3. The precipitate was filtered off and dried to give 0.300 g (92%) of the title product 9, which was used in the next step without an additional purification.

Workup

  1. additionwas added
  2. customTetrahydrofuran was evaporated
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-b40a2c9e3071409fa1024ac397077f7c
Source dataset
uspto-grants-2005_11
Patent number
US06960685B2

Reaction notes

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