反应详情

Triethylamine (1.46 mL, 10.45 mmol) was added to a suspension of 4-piperidinone trifluoroacetate (0.76 g, 3.58 mmol) in CH2Cl2 (10 mL) and a solution of 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carbonyl chloride in CH2Cl2 (5 mL) was added. The mixture was stirred at rt under argon for 17 h, diluted with CH2Cl2 (50 mL), washed with water (2×50 mL), dried over MgSO4, and concentrated to give 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol4-yl]carbonyl}-4-piperidinone as a yellow solid (0.96 g, 77%). MS (Electrospray) 414 (MH+), 1H NMR (300 MHz, CD2Cl2) δ 7.80 (s, 1H), 7.37-7.20 (m, 6H), 7.06-7.00 (m, 6H), 4.47 (br, 2H), 3.92 (br, 2H), 2.46 (t, 4H).

1. washwashed with water (2×50 mL)
2. dry with materialdried over MgSO4
3. concentrationconcentrated