Trifluoroacetic acid → HCID 22285483, compound

HRID 1062434Notes

Reaction equation

HRID 1062434 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=2)[C:10]([CH3:20])=[C:11]([C:13]([O:15]C(C)(C)C)=[O:14])[N:12]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=2)[C:10]([CH3:20])=[C:11]([C:13]([OH:15])=[O:14])[N:12]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22285461HCID 22285461, compound

Product 1

HCID 22285483HCID 22285483, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

t-Butyl 2-(2-chlorophenyl)-5-methyl-1-(4-nitrophenyl)-1H-imidazole-4-carboxylate (69 mg, 0.17 mmol) was dissolved in dry dichloromethane (2 mL) and treated dropwise with trifluoroacetic acid (2 mL). After stirring at rt for 2 h, the solution was concentrated to give 2-(2-chlorophenyl)-5-methyl-1-(4-nitrophenyl)-1H-imidazole-4-carboxylic acid as a yellow foam, which was used without purification in the preparation of Example 23.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-71e3723c18404560a04c6a3022a6fbae
Source dataset
uspto-grants-2005_11
Patent number
US06960601B2

Reaction notes

Loading…