Ethanol → Acetyl-L-phenylalanine ethyl ester

HRID 1062515노트

반응식

HRID 1062515 반응식
[NH:1]([C:13]([CH3:15])=[O:14])[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:16](O)[CH3:17]>Cl>[NH:1]([C:13]([CH3:15])=[O:14])[C@H:2]([C:10]([O:12][CH2:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 702EthanolHCID 74839N-Acetyl-L-phenylalanine

생성물 1

HCID 94229Acetyl-L-phenylalanine ethyl ester

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

To a solution of N-Ac-L-Phe (5.0 g, 24.1 mmol) in 120 ml of ethanol was added a few drops of concentrated HCl. The reaction mixture was refluxed overnight, then concentrated under reduced pressure. The residual solid was dissolved in ethyl acetate, washed twice with dilute NaHCO3, then once with water. The organic phase was dried over MgSO4, concentrated under reduced pressure, and dried under vacuum, to give N-Ac-Phe-OEt as a white solid.

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residual solid was dissolved in ethyl acetate
  4. washwashed twice with dilute NaHCO3
  5. dry with materialThe organic phase was dried over MgSO4
  6. concentrationconcentrated under reduced pressure
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-26bea3571fc94368a5dbcf84b1ab7259
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962899B2

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