Trifluoroacetic acid → HCID 69793632, compound

HRID 1062561Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][F:18])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[F:18][CH2:17][CH2:16][CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 22281346HCID 22281346, compound

Product 1

HCID 69793632HCID 69793632, compoundYield 87%

Procedure

A mixture of 1-tert-butoxycarbonyl-4-(4-fluoro-n-butyl)piperazine (3.50 g, 10.74 mmol) in trifluoroacetic acid (20 mL) was stirred at room temperature for 1 h. The reaction mixture was evaporated to dryness under vacuum and the resulting residue was triturated from Et2O to afford the titled compound (2.61 g, 87%) as a white solid.

Workup

customThe reaction mixture was evaporated to dryness under vacuum
customthe resulting residue was triturated from Et2O

Sources & evidence

ORD record: ord-8e272d1cc6a541a8bedc926811f7dd99
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06962911B2

Reaction notes

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